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Best Thyroid Supplement

The products featured in this article have been independently reviewed by a holistic health practitioner. Angela Halderson, RDN, CMS, is a certified health coach with experience providing nutritional counseling.

A pervasive exhaustion settles in. You feel overstressed yet underpowered. Ambition fades. Reaching for that extra cup of coffee becomes routine after restless nights. The numbers on the scale keep drifting higher. There may be more going on here than meets the eye.

For the millions struggling with such unexplained, draining symptoms, science points to an unlikely culprit: the thyroid. When this small gland located at the base of the neck fails to properly regulate metabolism-driving hormones, life-altering manifestations can follow.

Correcting dysfunctional thyroid biochemistry proves challenging, though strategic nutrition and select supplements may help reclaim vitality. We now turn to the latest research on supporting thyroid health to uncover pathways to renewal.

Why the Thyroid Is Important

The thyroid gland—a small, butterfly-shaped organ located at the base of the neck—has an enormously important role in regulating metabolism. It produces thyroid hormones, primarily T3 and T4, that help control critical bodily functions like heart rate, body temperature, breathing, digestion, muscle control, brain development, and bone maintenance. T3 is considered the more biologically active hormone that can directly influence cells, while T4 serves as somewhat of a reservoir that is converted to T3 when needed.

These hormones affect nearly all tissues and play a major regulatory role in controlling metabolism—utilizing energy, breaking down fats and proteins, controlling thermal homeostasis, supporting growth and development, and maintaining enzyme reactions. Basically, thyroid hormones influence the very speed of biochemical reactions.

Therefore, even small changes in thyroid hormone levels that result in low (hypothyroidism) or high (hyperthyroidism) production can trigger noticeable symptoms and health issues. Monitoring thyroid function through medical tests and supporting thyroid health through nutrition and supplements when necessary are important considerations.

Symptoms of Thyroid Dysfunction

Abnormal thyroid hormone levels resulting in hypothyroidism or hyperthyroidism can cause wide-ranging symptoms. Recognizing key signs of dysfunction empowers a person to seek proper testing and treatment. Common symptoms include:

  • Energy disruption: fatigue/weakness and intolerance to temperature shifts.
  • Weight changes: basal metabolic rate decrease; inefficient conversion of nutrients into energy; and underactive metabolism resulting in accumulation of fat.
  • Cognitive difficulties: memory/concentration loss; depression; and anxiety/irritability
  • Physiological alterations: menstrual irregularities; fertility challenges; and coma (in severe cases).
  • Outward manifestations: skin, nail, and hair changes; fluid accumulation; and swelling or enlargement.
  • Vital organ impact: digestive dysfunction; heart rhythm abnormality; and breathing impairment.

Catching thyroid dysfunction early and understanding both generalized and unique presentations enable healthcare providers to halt the progression and restore balance through proper diagnosis and personalized treatment approaches.

Thyroid Dysfunction and Weight Changes

A dysfunctional thyroid can lead to both weight loss (in cases of hyperthyroidism) and weight gain, but concerns about thyroid health most often arise when people struggle with gaining weight.

Weight gain can be a result of thyroid dysfunction. When the thyroid gland is underactive (hypothyroidism), it does not produce enough of the thyroid hormones T3 and T4. These hormones play an integral role in regulating metabolism.

With lower thyroid hormone levels in hypothyroidism, the body's basal metabolic rate decreases. This decrease means nutrients from food aren't being converted into energy as efficiently. Consequently, the underactive metabolism causes calories and fat to accumulate rather than being properly burned off.

In addition, thyroid hormones directly stimulate enzymes that mobilize fat for use as energy. With fewer hormones available, fat mobilization slows down. This slow-down promotes increased storage of fat despite normal calorie intake. Fluid retention or swelling may also contribute to weight gain in hypothyroidism.

Furthermore, many people with an underactive thyroid experience constant fatigue, weakness, and sleepiness. This effect contributes to a more sedentary lifestyle and decreased physical activity, reducing calories burned through exercise. This vicious cycle makes it quite difficult to manage or lose weight.

Compensating for this dysfunction with thyroid hormone replacement medication can help reverse hormone-related metabolic changes and resultant weight gain. However, some may continue battling excess weight until optimal hormone balance is achieved. Monitoring thyroid blood work proves useful for effectively regulating thyroid function and related body weight.

Common Thyroid Diseases

The most common thyroid diseases are:

  1. 1. Hyperthyroidism: When the thyroid gland produces excess thyroid hormones, causing symptoms like fatigue, weight loss, rapid heart rate, sweating, and anxiety. It is often caused by Graves' disease.
  2. 2. Hypothyroidism: When the thyroid gland does not produce enough thyroid hormones, leading to symptoms like fatigue, weight gain, sensitivity to cold, and depression. Common causes are Hashimoto's thyroiditis and surgical removal of the thyroid.
  3. 3. Goiter: A goiter is a noncancerous enlargement of the thyroid gland that can be related to iodine deficiency or hyperthyroidism/hypothyroidism. Larger goiters may cause coughing, trouble swallowing, or breathing issues.
  4. 4. Thyroid nodules: Abnormal growths or lumps in the thyroid gland are usually benign but can occasionally be cancerous. Larger nodules may cause neck swelling and discomfort.
  5. 5. Thyroid cancer: While rare compared to other thyroid conditions, thyroid cancer leads to nodules/lumps that can cause symptoms like throat tightness and trouble swallowing or breathing if the tumor grows larger.

Causes of Thyroid Dysfunction

What causes thyroid dysfunction? Here are a few of the main causes:

  1. 1. Autoimmune diseases: Hashimoto's disease and Graves' disease cause the immune system to attack the thyroid gland, leading to hypothyroidism and hyperthyroidism respectively.
  2. 2. Inflammation (thyroiditis): Thyroid inflammation from conditions like postpartum thyroiditis or subacute thyroiditis can cause thyroid hormone levels to fluctuate.
  3. 3. Nutrient deficiencies: Deficiencies in iodine, selenium, vitamin D, or zinc can interfere with proper thyroid hormone production.
  4. 4. Pituitary gland disorders: Tumors or other issues with the pituitary gland can disrupt the release of thyroid stimulating hormones (TSH) and cause too little or too much thyroid stimulation.
  5. 5. Some medications: Drugs like lithium, amiodarone, interferon alpha, interleukin-2, etc. have been associated with thyroid dysfunction.
  6. 6. Genetic factors: Genetic susceptibility or predisposition may contribute to a higher risk of thyroid problems.

The most common factors are autoimmunity, inflammation, nutrient deficiencies, effects of other treatments, and for some individuals, a genetic predisposition. Recognizing the root cause may help guide proper management.

Reasons to Take a Thyroid Supplement

"Supplements specially formulated for the thyroid help support thyroid function," says Angela Halderson, RDN, CMS, an Integrative and Functional Nutritionist with Natural Healthy Concepts. "The thyroid is part of the endocrine system and makes hormones responsible for stimulating the nervous system. Thyroid hormones help us wake up, stay alert, digest our food and even help regulate heart rate.”

“Someone with an underactive thyroid may have dry skin, hair loss, cold hands or feet, constipation, general fatigue or even high cholesterol. Someone with an overactive thyroid may have symptoms of mood swings, difficulty sleeping, heat sensitivity, or trouble maintaining a healthy weight. Thyroid supplementation helps provide the thyroid with the nutrition it needs to function better, making the organ stronger and less prone to stressful fluctuations," adds Halderson.

These are some common reasons why taking a quality thyroid supplement can be beneficial:

  • Provide thyroid nutrition: Compensate for dietary deficiencies in nutrients needed to produce thyroid hormones, like iodine, selenium, zinc, and tyrosine.
  • Support healthy T4-T3 conversion: Assist with the conversion of T4 into the more metabolically active T3 thyroid hormone.
  • Maintain metabolism and weight: Counteract metabolic changes from low thyroid function to potentially aid weight management.
  • Relieve thyroid-related symptoms: Help alleviate common symptoms tied to hypothyroidism like fatigue, weight gain, dry skin, hair loss, cold sensitivity, and constipation.
  • Autoimmune support: Some ingredients may calm autoimmune reactions involved in Hashimoto’s disease.
  • Overall wellness: Support whole-body health, stress adaptation, hormone balance, and healthy aging since thyroid hormones influence widespread biochemical reactions.

How to Choose a Thyroid Supplement

When selecting a thyroid supplement there are several key factors to evaluate:

  1. 1. Nutrient forms: Seek supplements providing nutrients in bioavailable, high-quality forms for optimal absorption and utilization. Chelated minerals and vitamins in their natural forms are ideal.
  2. 2. Effective dosages: Verify clinically supported doses of nutrients, particularly iodine, selenium, zinc, and tyrosine to maintain thyroid hormone status.
  3. 3. Quality ingredients: Ensure high-purity ingredients free from unnecessary additives and allergens for safety and tolerability.
  4. 4. Third-party testing: Choosing products verified for purity and potency through independent laboratory testing provides confidence in what you’re taking.
  5. 5. Trusted brand: Reputable manufacturers adhering to current Good Manufacturing Practices (cGMP) for sourcing, processing, and labeling inspire greater trust.

With these criteria in mind, the professional picks below rise to the top as high-quality, discerningly formulated thyroid support supplements.

Professional Picks

With many thyroid supplements currently available, deciding which one to take can be challenging. Here we cover three evidence-based professional quality options.

Restorative Formulations Thyroid Px

Thyroid Px by Reformative Formulations takes a balanced herbal-nutraceutical approach to optimizing thyroid function. Combining thyroid-essential vitamins and minerals with traditional Ayurvedic botanicals provides complete nutritional support for maintaining healthy thyroid hormone levels and metabolism.

The backbone minerals iodine, selenium, and zinc are included alongside vitamin D and activated B12 to promote proper thyroid hormone synthesis and cellular energy production. Tyrosine and antioxidants further assist with thyroid hormone activation and protection from free radical damage.

The blend is rounded out by ingredients from traditional Ayurvedic plants like ashwagandha, ginger, and Triphala paired with thyroid-supportive sea botanicals bladderwrack and nettle. These ingredients supply bioactive compounds that bolster thyroid nutrient status, equilibrium, and strain resilience.

  • Form: Veg capsules
  • Serving Size: 2 capsules
  • Suggested Use: 1–2 servings twice daily, up to 4 capsules twice daily for 3 months maximum.
  • Servings per Container: 37

Priority One Thyroid 65

Delivering direct nutritive support, Thyroid 65 by Priority One includes 65 mg of bovine thyroid extract per capsule. As a natural source of thyroid hormones T3 and T4, it acts to reinforce hormone status at the direct biosynthetic level. This glandular approach dates back to early medical practices for confronting low thyroid function.

Sourced from pasture-raised New Zealand cattle and purified under strict quality controls, Priority One’s Thyroid 65 provides natural nutritional cofactors alongside active thyroid hormones. This single-ingredient formula allows for individualized dosing and flexible use alongside other targeted thyroid support nutrients if desired.

  • Form: Capsules
  • Serving Size: 1 capsule
  • Suggested Use: 1 capsule daily, up to 4 capsules daily
  • Servings per Container: 90

NutriDyn Thyroid Complex

Thyroid Complex by NutriDyn supplies a research-backed combination of vitamins, minerals, and amino acids to provide multidimensional support for healthy thyroid hormone activation and metabolism. Alongside foundational iodine and selenium, it includes activated forms of B vitamins, antioxidants A, C, and E, plus tyrosine and Rhodiola rosea to assist energy production, hormone synthesis, and defense against oxidative damage.

The ingredient forms and dosages are aligned with clinical research demonstrations of efficacy for moderating thyroid function and maintaining wellness. As a condition-specific complex backed by current scientific evidence and ethically produced under stringent quality guidelines, NutriDyn Thyroid Complex is an ideal choice for fortifying whole-body health.

  • Form: Capsules
  • Serving Size: 1 capsule
  • Suggested Use: 1 capsule 3 times daily
  • Servings per Container: 90

What Recent Research Is Saying

While extensive information already exists on common thyroid conditions and conventional treatment approaches, new research continues uncovering additional aspects influencing thyroid function. Here is a quick summary of some of the latest research on thyroid health:

1. Importance of Nutrients

Recent studies continue to demonstrate the importance of nutrients like iodine, selenium, zinc, iron, vitamin D, B vitamins, and antioxidants for optimal thyroid hormone production and activity. Deficiencies in these nutrients can exacerbate hypothyroidism.

2. Gut Health Connections

Emerging research shows a clear link between gut microbiome imbalance and Hashimoto’s disease. Addressing gut permeability and inflammation, as well as fostering microbiome diversity, may benefit autoimmune thyroid conditions.

3. Potential Environmental Influences

Increased investigation around environmental toxins and endocrine disruptors indicates early life and ongoing exposures could negatively impact thyroid function in genetically susceptible individuals. These include perchlorate in produce, BPAs in plastics, fluoride in water, and pollutants in fish.

4. Dietary Considerations

Newer diet analyses reveal associations between highly processed, high glycemic load foods and poorer thyroid function. Similarly, data supports certain diets (gluten/dairy free, Mediterranean, anti-inflammatory) benefiting autoimmune thyroid patients.

5. Individual Variability Prominence

Genetic polymorphisms and personalized markers outside the standard TSH/T4 testing can provide clearer insight into an individual’s unique thyroid physiology for more precise, tailored interventions. These include reverse T3, anti-TPO antibodies, basal temperature, nutrient status tests, and advanced hormone panel testing.

The growing research continues to solidify the importance of nutrients, diet, lifestyle modifications, and personalized approaches as integral to supporting optimal thyroid performance.

Frequently Asked Questions

Thyroid Disorders and Their Symptoms

What are the most common thyroid disorders I should be aware of?

The most prevalent thyroid disorders are hypothyroidism, hyperthyroidism, Hashimoto’s thyroiditis (autoimmune hypothyroid), and Graves’ disease (autoimmune hyperthyroid). Blood tests examining thyroid hormone levels (TSH, T4, T3) along with thyroid antibodies can diagnose which condition may be present.

What signs and symptoms might indicate my thyroid is not functioning properly?

Common symptoms that can signal hypo or hyperthyroidism include fatigue, unexpected weight changes, feeling cold or hot, muscle weakness, dry skin and hair, constipation, depression, trouble concentrating, memory loss, and irregular or heavy menstruation.

What steps should I take if I suspect I have a thyroid disorder?

Here are the steps you should take if you suspect you have a thyroid issue contributing to your health problems:

1. Track your symptoms. Document any symptoms possibly related to thyroid dysfunction like unusual fatigue, unexpected weight gain or loss, feeling cold or hot all the time, hair thinning, depression, trouble concentrating, etc. Tracking symptoms helps identify patterns.

2. Get lab testing. Make an appointment with your healthcare provider to get standard thyroid blood tests ordered including TSH, free T4, free T3, reverse T3, and thyroid antibodies (TPO, TGB). These help diagnose thyroid dysfunction. Vitamin and mineral markers can also identify nutritional deficiencies taxing the thyroid.

3. Follow-up testing. Depending on initial results, your provider may order additional tests like a thyroid ultrasound, basal body temperature readings, complete hormone panel, micronutrient analysis, food sensitivity testing, or genetic SNP variance testing related to thyroid health. These can provide more clarity.

4. Seek specialist referrals. If lab results demonstrate thyroid dysfunction or autoimmunity issues that require more targeted treatment, your provider may refer you to an endocrinologist, immunologist, functional/integrative medicine doctor, or naturopathic doctor specializing in thyroid disorders for advanced testing and corrective protocols.

5. Discuss treatment options. Work collaboratively with your doctor(s) to determine the best course of treatment, which may include thyroid hormone replacement/modulating medications, dietary changes, targeted supplementation, gut healing protocols, detoxification, stress reduction techniques, and close lab monitoring to achieve optimal results.

How to Support Thyroid Health with Nutrition

What foods are considered beneficial for supporting thyroid function?

Nutritional sources that support thyroid function include iodine and selenium-rich foods like seafood, eggs, dairy, liver, lima beans, and spinach. Antioxidant-packed fruits and high-quality proteins like meat and poultry are also helpful. Add nuts and seeds to the list as well.

"The thyroid needs three basic minerals to function optimally: zinc, iodine, and selenium. Zinc is used by the thyroid to make Thyroid Stimulating Hormone (TSH). Iodine is needed to make thyroxine. This is commonly referred to as T-4, or inactive thyroid hormone. Selenium is used to activate T-4 to become T-3, the active thyroid hormone," says Halderson. "Herbs can also be used to support thyroid function. Kelp, seaweed or miso soup are natural sources of iodine. Coleus Forskohlii is an herb commonly used to help the thyroid make more T-3. Ashwagandha is an adaptogenic herb that not only supports adrenal function, but can also be used by the body to help stimulate levels of T-4. An over-active thyroid can be supported by calming herbs like Lemon Balm, Bungleweed or Motherwort."

"When considering nutritional support for the thyroid, consider the above nutrients," Halderson adds. "It is more economical to reach for a comprehensive supplement designed to support proper thyroid function. These can combine minerals, amino acids, glandulars and herbs together. My favorite go-to's for my thyroid are Thyroid Support and Thyroid Support Complex. Balance your diet with foods supportive to underactive thyroid like oysters, red meat, liver, brazil nuts and miso soup. Avoid high iodine intake if you are struggling with an overactive thyroid."

Are there any foods I should try to avoid if I have thyroid issues?

Avoiding cruciferous raw vegetables may be prudent. Cruciferous vegetables are things like broccoli, cauliflower, Brussels sprouts, kale, cabbage, etc. These veggies contain compounds called goitrogens which at high intake levels could potentially disrupt thyroid function by interfering with iodine uptake. However, this is mostly a concern when eating these cruciferous veggies raw and in very high amounts.

Cooking cruciferous vegetables can deactivate the goitrogenic compounds. So eating moderate amounts of cooked cruciferous veggies is typically not a problem for thyroid health. However, some functional medicine practitioners still advise those with hypothyroidism or Hashimoto's to limit the over-consumption of raw cruciferous vegetables to err on the side of caution.

A few additional foods thought to potentially disrupt thyroid function include soy, gluten, refined flour, and sugars. Also, minimize exposure to potential thyroid hormone disruptors through food like BPAs from plastics and perchlorate from certain produce.

What key nutrients in addition to iodine and selenium are important for thyroid health?

In addition to iodine and selenium, zinc, iron, vitamin D, B vitamins (B2/riboflavin, B3/niacin, B6, B12), vitamin A, antioxidants C and E, and the amino acid tyrosine play roles in thyroid hormone production. They are also factors in protecting against oxidative damage.

Best Supplements for Thyroid Health

What supplements are typically recommended for supporting my thyroid?

Common thyroid-supporting supplements include iodine, selenium, zinc, tyrosine, vitamin D, B complex, ashwagandha, bladderwrack seaweed, probiotics and/or digestive enzymes, omega 3s, adaptogens, and bovine thyroid glandulars. See the professional picks in this article for several preferred options.

Are there any herbal remedies or other natural supplements that can help?

Certain Ayurvedic herbs (ashwagandha, guggul, ginger), sea botanicals (bladderwrack, kelp), compounds (L-carnitine, alpha lipoic acid), and probiotics favor thyroid physiology and offer additional holistic support. Some find thyroid glandular supplements effective as well.

When would taking an iodine supplement be advised for thyroid health?

Those eating processed, non-organic, and iodine-deficient diets may benefit from iodine supplementation alongside selenium to promote healthy thyroid hormone production. For autoimmune Hashimoto’s, check antibody levels first since iodine intake needs to be carefully monitored.

Side Effects of Thyroid Supplements

What potential side effects should I watch out for with thyroid supplements?

If experiencing symptoms of hyperthyroidism (heart palpitations, tremors, rapid weight loss, etc.) thyroid supplements may need to be adjusted under your healthcare provider’s guidance, especially if taking thyroid hormone replacements.

Can I take too much of certain supplements meant for the thyroid?

Consuming extremely high amounts of iodine, selenium, and bovine thyroid extracts could theoretically agitate the thyroid. Stick within standard dosage guidelines for thyroid supplements to stay in optimal safe ranges. Talk with a health professional if adverse reactions occur.

Should I be concerned about interactions with medications?

Be aware thyroid supplements may interact with certain medications including statins, hypertension drugs, antidepressants, pain relievers, and estrogen. Check with your prescribing doctor about any interactions with thyroid supplements and dosage adjustments needed. Monitoring thyroid blood markers helps guide appropriate supplementation.


As thyroid dysfunction can spur profound fatigue, unplanned weight fluctuations, cardiovascular disturbances, and mood instability, restoring optimal hormonal balance proves imperative for reestablishing whole-body health and vitality. While medication has its place for moderating thyroid performance, strategic supplementation may enable the body to regenerate more holistically.

When selecting a thyroid supplement, discerning factors like bioavailability, contaminant-free purity, third-party verification, and a reputable cGMP-compliant manufacturer helps ensure safety and efficacy. Premier supplements combine iodine, tyrosine, selenium, zinc, vitamins, and antioxidants with traditional botanicals like ashwagandha, nettle, and bladderwrack for comprehensive support. Those providing endocrine extracts or glandulars offer more direct thyroid reinforcement as well.

In the quest to revive thyroid well-being, professional-grade supplements, like the ones featured in this article, address faltering function at multiple intersecting pathways. Potent glandular extracts or nutrients like iodine replenish depleted reserves immediately available for hormonal production while antioxidants and botanicals strengthen strain resilience and calm inflammation long-term. A strategic thyroid supplement reinforces the foundation upholding energetic equilibrium, healthy weight, and peak performance.

As with any therapeutic compound, working under the guidance of a trusted practitioner optimizes safe, effective integration on one’s renewal journey.

How We Chose the Best Quercetin Supplements

For the ranking, the editorial team consulted with an accredited nutrition expert. Ratings were based on user satisfaction, cost and third-party certification, and determined solely by the editorial team.

All product prices are accurate as of publication and are subject to change.