The New Gold Standard for Menopausal Relief

Submitted by Metagenics

Estrovera is a natural option that features ERr 731, a special extract of Siberian rhubarb, demonstrated in clinical studies to significantly reduce menopausal symptoms—offering an effective and safer option for both peri- and postmenopausal women.*

Effective Relief for Menopausal Symptoms*

Clinically shown to dramatically reduce the number of daily hot flashes and relieve a wide range of other symptoms.*

Efficacy Comparable to Hormone Therapies*

Demonstrated to relieve hot flashes to a similar extent as estrogen-based therapies and exceed reported results of other phytoestrogen and botanical approaches.*

Unprecedented Scientific Validation for a Phytoestrogen Approach*

Multiple short- and long-term studies with over 400 peri- and postmenopausal women— published in peer-reviewed journals—confirm efficacy and predicted safety*. For example:

• In a 12-week clinical study with ERr 731, perimenopausal women reported significant improvements in symptoms—including hot flashes and anxiety—within just 28 days (compared to placebo)*[3,4]

• In another 12-week clinical study, ERr 731 reduced average number of daily hot flashes from 12 to 2*[5]

• In a six-month study, ERr 731 demonstrated progressive relief of multiple symptoms measured by the Menopause Rating Scale (MRS), including:*[1]

—Negative mood, irritability & anxiety

—Joint and muscle discomfort

—Physical/mental exhaustion

—Sleep disturbances

—Hot flashes/night sweats

• In a two-year study with ERr 731, ~83% reduction of the total MRS II score was maintained from 60 weeks to 108 weeks*[2]

• Estrovera provides a clinically effective dose of ERr 731 in just 1 tablet daily*

Excellent Safety Profile*

ERr 731 has been professionally recommended for over 20 years with no serious adverse events reported and no clinically relevant changes in safety parameters have been observed in clinical trials.*

References

1. Altern Ther Health Med. 2008;14(6):32-38.

2. Menopause. 2009;16(1):117-131.

3. Menopause. 2006;13(5):744-759.

4. Menopause. 2007;14(2):270-283.

5. Altern Ther Health Med. 2009;15(1):24-34.

*This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.