Contains non-glandular ingredients important for adrenal health and reducing stress-induced fatigue*
L-methionine: Precursor to S-adenosylmethionine (SAMe) (1). SAMe is directly involved in methylation processes including catecholamine synthesis (2).
L-tyrosine: Precursor to catecholamines including dopamine, norepinephrine, and epinephrine.
L-histidine: Precursor to histamine. In the central nervous system, histamine plays an important role in the release of pituitary hormones and wakefulness (3).
Rhodiola rosea root extract (5% rosavins): Adaptogen that has been shown to reduce stress-induced effects (4,5).* In a randomized, double-blind, placebo-controlled study, Rhodiola rosea was shown to significantly reduce mental fatigue and improve general well-being under stress (5).*
Green tea leaf extract (Camellia sinensis) (65% EGCG): Epigallocatechin gallate (EGCG) is a polyphenol in green tea that provides antioxidant protection by its ability to scavenge free radicals and metal ions (6).* EGCG has been shown to increase resistance to fatigue in vivo (7).*
Vitamins B and C: Active forms of pantothenic acid, niacin, B6, folate, B12, and C are important for the synthesis of adrenal hormones and neurotransmitters (8-12).*
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
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2. Mischoulon D and Fava M. Am J Clin Nutr. 2002;76(5):1158S-61S.
3. Krystal A, et al. Sleep Med Rev. 2013;17(4):263-72.
4. Chiang H, et al. J Food Drug Anal. 2015;23(3):359-69.
5. Spasov A, et al. Phytomedicine. 2000;7(2):85-9.
6. Legeay S, et al. Nutrients. 2015;7(7):5443-68.
7. Teng Y and Wu D. Pharmacogn Mag. 2017;13(50):326-31.
8. Ragaller V, et al. J Anim Physiol Anim Nutr (Berl). 2011;95(1):6-16.
9. Vrecko K, et al. Biochim Biophys Acta. 1997;1361(1):59-65.
10. May J, et al. Brain Res Bull. 2013;90:35-42.
11. Antoniades C, et al. Circulation. 2006;114(11):1193-201.
12. Mattson M and Shea T. Trends Neurosci. 2003;26(3):137-46.