To further facilitate serotonin production, Thorne Research 5-HTP formula contains pyridoxal 5-phosphate, the active form of vitamin B6 and the necessary cofactor for the conversion of 5-HTP to serotonin.* 5-HTP is commercially produced by extraction from the seeds of the African plant, Griffonia simplicifolia.
5-Hydroxytryptophan (5-HTP) is the intermediate metabolite produced when the body initiates the process of converting the essential amino acid L-tryptophan to serotonin. Serotonin levels in the body are associated with the regulation of sleep, mood, aggression, appetite, temperature, sexual behavior, and pain sensation.*
Increases serotonin levels for sleep enhancement, decreased sugar cravings, and better stress management*
Can be taken with meals without competing with other amino acids
Includes vitamin b6 for optimal activity
Made without flowing agents that can inhibit bioavailability
Supplementing with 5-HTP to facilitate serotonin production is preferable to supplementing with L-tryptophan because, unlike L-tryptophan, 5-HTP cannot be shunted into niacin or protein production.*
Supplementation with 5-HTP bypasses the conversion of L-tryptophan into 5-HTP by the enzyme tryptophan hydroxylase, the rate-limiting step in the synthesis of serotonin and a step that can be inhibited by a number of factors, including stress, insulin resistance, increasing age, and deficiencies of vitamin C, folate, and iron.
5-HTP is well absorbed when taken orally, with about 70 percent ending up in the bloodstream.* Intestinal absorption of 5-HTP does not require the presence of a transport molecule and is not affected by the presence of other amino acids; therefore, it may be taken with meals without reducing its usefulness.* 5-HTP easily crosses the blood-brain barrier and usefully increases central nervous system (CNS) synthesis of serotonin.*
5-HTP has been shown to have a beneficial impact on mood, discomfort associated with fatigue, sleep, and carbohydrate craving.* Numerous studies of individuals with negative mood status have shown significant positive response with 50-300mg of 5-HTP daily.*
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Recommended Use: Adults: Take 1 to 2 capsules 3 times per day or as recommended by a healthcare professional.
Warning: A woman who is pregnant, or who might become pregnant, should not use 5-hydroxytryptophan. 5-hydroxytryptophan is specifically contraindicated during pregnancy. Should be used with caution with prescription anti-depressants. Keep out of the reach of children.
Began taking this about 5 months ago. Excellent alternative!
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It was recommended. By my Acupuncturist. I have have utilizing it for sleep & have been pleased with its effectiveness .
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AM definitely flattens my mood, keeping me focused all day. PM allows me to nod off at a regular hour. Very cool stuff. Will always take this and recommend.
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