Trifolamin™ lozenges provide a synergistic combination of the three bioavailable forms of vitamin B12, as methylcobalamin, hydroxycobalamin, and adenosylcobalamin, with the natural active form of folate as [6s]-5-methyltetrahydrofolate. These three forms of B12 are naturally present in foods, and can be readily converted in the body to the active intracellular forms of B12. Trifolamin™ lozenges are formulated to support healthy levels of vitamin B12. Folate is included because it is one of the most important cofactors that helps realize the benefits of optimizing B12 status. Trifolamin’s lozenge delivery system allows for optimal absorption of B12 and folate. It is best to take Trifolamin™ after a meal, and to allow the lozenge to dissolve slowly and completely in the mouth before swallowing. 

The three forms of B12 found in Trifolamin™ can be readily converted to the active intracellular forms of B12, such as methylcobalamin, adenosylcobalamin, glutathionylcobalamin, and possibly other physiologically active B12 forms. Folate’s inclusion is important because it works synergistically with vitamin B12 in supporting methylation and cell replication, and in helping to promote balanced concentrations of homocysteine. 

Trifolamin™ uses a lozenge delivery system, allowing for two routes of absorption for vitamin B12 and folate: 1) directly through the oral mucosa, and 2) bound by haptocorrin (binding protein secreted in saliva) and carried to the GI tract.