- Brand: Neuroscience
- Product Code: calm-cp-NSC
- Servings per Container: 30
- Quantity per Container: 60 Capsules
Decreases cortisol levels and provides ingredients important for calm, sleep, and management of blood sugar*
Lagerstroemia speciosa (Banaba) leaf extract (2% corosolic acid): Corosolic acid selectively inhibits 11B-hydroxysteroid dehydrogenase 1 (11B-HSD1), an enzyme that catalyzes the conversion of cortisone into cortisol (1,2).* In a randomized study, corosolic acid was shown to significantly lower blood glucose levels by 20-30% after two weeks (3).*
Phosphatidylserine: Component of cell membranes important for receptor-mediated interactions (4).* Phosphatidylserine is thought to interact with cell membranes in order to dampen hypothalamic signaling and regulate the stress response (5).*
Glycine: Major inhibitory neurotransmitter that crosses the blood-brain barrier (6).* Binds receptors that regulate temperature during sleep (7).*
Taurine: Neuroprotective amino acid that provides antioxidant protection and demonstrates GABA-A agonist activity (8-10).* GABA is the primary inhibitory neurotransmitter in the brain important for calm and sleep (11-13).
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
1. Rollinger J, et al. Bioorg Med Chem. 2010;18(4):1507-15.
2. Patel H, et al. Arabian Journal of Chemistry. 2015.
3. Judy W, et al. J Ethnopharmacol. 2003;87(1):115-7.
4. Monteleone P, et al. Eur J Clin Pharmacol. 1992;41:385-8.
5. Glade M and Smith K. Nutrition. 2015;31(6):781-6.
6. Kawai N, et al. Amino Acids. 2012;42(6):2129-37.
7. Kawai N, et al. Neuropsychopharmacology. 2015;40(6):1405-16.
8. Kumari N, et al. Adv Exp Med Biol. 2013;775:19-27.
9. Shimada K, et al. Adv Exp Med Biol. 2015;803:581-96.
10. Kletke O, et al. PLoS One. 2013;8(4):e61733.
11. Gou Z, et al. Dongwuxue Yanjiu. 2012;33(E5-6):E75-81.
12. Mohler H. Neuropharmacology. 2012;62(1):42-53.
13. Saper C, et al. Nature. 2005;437(7063):1257-63.
2 capsules contains:
Proprietary Blend 1.2g:
---Lagerstroemia speciosa (Banaba) leaf extract (2% corosolic acid), Phosphatidylserine enriched soy lecithin, Glycine and Taurine
Other Ingredients: vegetable capsule (HPMC, water), microcrystalline cellulose, magnesium stearate (vegetable source), silicon dioxide. Contains lecithin from soy.
Adults: Take 2 capsules one to two times daily. Use under supervision of a licensed healthcare practitioner.
If you are pregnant or nursing, consult your healthcare practitioner before use. KEEP AWAY FROM DIRECT SUNLIGHT. KEEP OUT OF REACH OF CHILDREN.