{"product_id":"dao-enzyme-by-pure-encapsulations","title":"Dao Enzyme, by Pure Encapsulations","description":"\u003ch3\u003eBenefits \u0026amp; Features\u003c\/h3\u003e\u003cul\u003e\n\u003cli\u003ePromotes breakdown of dietary histamine*\u003c\/li\u003e\n\u003cli\u003eReduces gastrointestinal discomfort (occasional diarrhea, bloating and gas) associated with sensitivity to histamine-rich foods*\u003c\/li\u003e\n\u003cli\u003eEat with greater confidence when histamine may be present in food*\u003c\/li\u003e\n\u003cli\u003eAcid-resistant capsules protect DAO from degradation in the stomach\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cbr\u003eHistamine is a substance found in many foods, such as meats, spinach, fermented foods, avocadoes, nuts, tomatoes and chocolate. An estimated 1-3% of the population cannot digest dietary histamine efficiently, often because of low intestinal diamine oxidase (DAO), an enzyme in the GI tract that normally breaks down histamine. These individuals often experience gastrointestinal discomfort, headache, skin sensitivity or flushing after consuming histamine-containing foods.1 Supplementation with DAO enhances DAO activity in the GI tract, promoting breakdown of dietary histamine and reducing gastrointestinal discomfort (occasional diarrhea, bloating and gas) associated with sensitivity to histamine-rich foods.3 DAO may also reduce skin symptoms associated with high intestinal histamine levels.6 In an open-label pilot study, individuals with low DAO levels (\u0026lt; 10 U\/ml) who received DAO (10, 000 HDU) up to 3 times per day reported significant improvements in gastrointestinal, respiratory and skin symptom scores after 4 weeks. Subjects reported significant improvement in gastrointestinal comfort, including occasional diarrhea, bloating and gas, headache, respiratory and skin discomfort.3 In a double-blind, placebo-controlled, crossover investigation of 22 patients, supplementation of 10, 000 HDU DAO twice daily for 30 days improved dietary histamine-associated skin discomfort.6 *\u003c\/p\u003e\u003ch3\u003e\n\u003cbr\u003eReferences\u003c\/h3\u003e\u003col\u003e\n\u003cli\u003eComas-Basté O, Sánchez-Pérez S, Veciana-Nogués MT, et al. Biomolecules. 2020 Aug 14;10(8):1181.\u003c\/li\u003e\n\u003cli\u003eSánchez-Pérez S, Comas-Basté O, Costa-Catala J, et al. Front Nutr. 2022 May 25;9:897028.\u003c\/li\u003e\n\u003cli\u003eSchnedl WJ, Schenk M, Lackner S, et al. Food Sci Biotechnol. 2019; 28(6): 1779-1784.\u003c\/li\u003e\n\u003cli\u003eManzotti G., Breda D., Di Gioacchino M., Burastero S.E. Int J Immunopathol Pharmacol. 2016;29:105–111.\u003c\/li\u003e\n\u003cli\u003eKomericki P., Klein G., Reider N., et al. Wien Klin Wochenschr. 2011;123:15–20.\u003c\/li\u003e\n\u003cli\u003eYacoub MR, et al. Int Arch Allergy Immunol. 2018;176(3-4):268-271.\u003c\/li\u003e\n\u003c\/ol\u003e\u003cp\u003e\u003cbr\u003e*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.\u003c\/p\u003e\u003ch2\u003eSuggested Usage\u003c\/h2\u003e\u003cp\u003eAs a dietary supplement, take 1 capsule, 2-3 times daily, with each meal, or as directed by a health care professional.\u003c\/p\u003e\u003ch2\u003eIngredients\u003c\/h2\u003e\u003cp\u003eServing Size: 1 Capsule\u003c\/p\u003e\u003cp\u003eAmount Per Serving:\u003c\/p\u003e\u003cul\u003e\u003cli\u003ePorcine kidney extract 4.2 mg\u003cbr\u003e- (providing 0.55 mU diamine oxidase (DAO) activity)\u003c\/li\u003e\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eOther ingredients:\u003c\/strong\u003e hypoallergenic plant fiber (cellulose), acid- resistant vegetarian capsule (cellulose, pectin, glycerol, purified water)\u003c\/p\u003e\u003ch2\u003eWarnings\u003c\/h2\u003e\u003cp\u003eIf you are pregnant or lactating, have any health condition or are taking any medication, consult your health professional before use.\u003c\/p\u003e\u003cp\u003eKeep out of reach of children.\u003c\/p\u003e\u003ch2\u003eAdditional Information\u003c\/h2\u003e\u003cp\u003eStore in a cool, dry place.\u003c\/p\u003e\u003cp\u003eGluten Free; Non GMO\u003c\/p\u003e","brand":"Pure Encapsulations","offers":[{"title":"60 Capsules","offer_id":52439844192556,"sku":"dao-enzyme-PEC : dao-enzyme-PEC-60-cpsls","price":49.99,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0938\/0030\/0844\/files\/dao-enzyme-PEC_main_1.jpg?v=1767907003","url":"https:\/\/www.nhc.com\/products\/dao-enzyme-by-pure-encapsulations","provider":"Natural Healthy Concepts","version":"1.0","type":"link"}