Pure Encapsulations Nrf2 Detox
Product Details
Brand: Pure Encapsulations
Category: Cleanse & DetoxProduct Code: nrf2-detox-PEC
Servings per Container: 60
Quantity per Container: 60 Capsules
Nrf2 Detox
Nrf2 and detoxification support
Cruciferous vegetables of the brassica family have long been recognized for their ability to support detoxification thereby maintaining healthy cells and tissues. Cruciferous vegetables, like broccoli, cauliflower, Brussels sprouts and kale, are the richest sources of glucosinolates, which are considered to be the most bioactive constituents. Glucosinolates are converted in the body to isothiocyanates after they are ingested and hydrolyzed. The isothiocyanate sulforaphane is one of the most powerful activators of phase II enzyme function in the liver, supporting toxin elimination. Sulforaphane and resveratrol promote the activity of nuclear factor erythroid 2-related factor 2 (Nrf2), a transcription factor that supports robust, long-lasting expression of numerous genes responsible for detoxification and protection against oxidative stress. Among these genes are glutathione peroxidase, superoxide dismutase and various phase II enzymes, such as glutathione sulfotransferases. Nrf2 also supports expression of glutathione glutamylcysteinyl ligase, which is responsible for a critical step in the biosynthesis of glutathione, a vital component of cellular antioxidant and detoxification systems. Found in virtually every cell of the body, glutathione plays essential roles in protein synthesis, synthesis and repair of DNA, enzyme function, transport, and cell maturation. Optimal levels of glutathione have been associated with physical and mental health. The highest concentration of glutathione is found in the liver, where it offers antioxidant support, protects tissue and maintains detoxification. In a randomized clinical trial, supplementation with 250 and 1,000mg of Setria glutathione per day increased glutathione levels in the blood after one, three and six months. At six months, mean glutathione levels in the high-dose group increased 30-35% in erythrocytes, plasma and lymphocytes, and 260% in buccal cells (P<0.05). In the low-dose group, mean glutathione levels increased 17% and 29% in blood and erythrocytes, respectively (P<0.05). Both glutathione dose groups showed support for antioxidant defenses, indicated by decreases in the oxidized-to-reduced-glutathione ratio in whole blood after six months.
Three-ingredient combination designed to support detoxification and antioxidant defenses.
Professional-grade products adhere to the strictest standards for purity and potency, and use the highest-grade ingredients available.
Suggested Usage
As a dietary supplement, take 1 capsule, 1–3 times daily, with meals.
Ingredients
- Serving Size: 1 capsule
- Servings Per Container: 60
- Amount Per Serving:
- Broccoli 250 mg
- -(Brassica oleracea italica) sprout concentrate (whole plant)(standardized to contain 1,000 mcg sulforaphane)
- Setria® glutathione (reduced form) 250 mg
- resVida® resveratrol (as trans-resveratrol) 15 mg
Other Ingredients: vegetarian capsule (cellulose, water)
Gluten free. Non-GMO.
Warnings
If you are pregnant or lactating, have any health condition or are taking any medication, consult your health professional before use.
It is recommended to use resveratrol cautiously in patients with hormonal disorders and those using estrogen therapy, as resveratrol may act as either an estrogen agonist or estrogen antagonist. Consult your physician for more information.
Some studies have reported that broccoli sprout extract can affect the way that the liver breaks down medications metabolized by the cytochrome P450 system, altering the effects of these medications and possibly the dose needed for treatment.
Resveratrol and broccoli sprout extract may react with blood thinning medications. Consult your physician for more information.
Keep out of reach of children.
Additional Information
Use only if safety seal is intact.
Store in a cool, dry place.