L-Carnitine from Douglas Labs contains 250mg of L-Carnitine per capsule. L-Carnitine is necessary for supporting fatty acid metabolism and energy production in cardiac and skeletal muscle*.
- Supports fatty acid metabolism and energy production in cardiac and skeletal muscle*
L-Carnitine is involved in fatty acid oxidation as part of the carnitine shuttle. L-carnitine shuttles fatty acids from the cytosol (the cell fluid) into the mitochondria (the cells powerhouses) for oxidation and energy production*.
L-carnitine is necessary in muscle whenever fat is utilized as an energy source. Heart muscle always uses fat for its continuous energy demands. Skeletal muscle begins using fat only after its glycogen reserves are exhausted. This happens after about one hour of continuous, strenuous exercise, e.g., long-distance running, bicycling, swimming, or mountain climbing.*
Widely distributed in foods from animal, but not plant sources, L-carnitine is also synthesized by the liver and kidney from two essential amino acids, lysine and methionine. Human skeletal and cardiac muscles contain relatively high L-carnitine concentrations which they receive from plasma, since they are incapable of L-carnitine biosynthesis themselves*.
About 95 % of the bodys L-carnitine stores are located in skeletal and heart muscle. L-carnitine is considered a conditionally essential nutrient. In healthy people, plasma L-carnitine levels are adequately maintained by the bodys own synthesis and dietary sources.
However, low L-carnitine plasma levels may be caused by hereditary (primary) L-carnitine deficiency syndrome, or by secondary L-carnitine deficiency. Patients with heart failure may excrete large amounts of L-carnitine in their urine*.
Oral L-carnitine is readily absorbed across the intestinal mucosa and into the bloodstream. It is then taken up from the portal vein into the liver and subsequently released into the systemic circulation. Most cells have a specific carnitine transporter*.
Dietary L-carnitine comes mainly from animal foods. Average non-vegetarian diets provide about 100 to300 mg of L-carnitine per day. Vegetarian diets often provide only trace amounts, since vegetables, fruits, and cereals are negligible sources of L-carnitine*.