Logo NHC

Which Mushroom Supplement is Best for Me?

mushroom supplements
Mushrooms are a popular healthy food choice. As an adaptogenic food, they can improve heart health, boost mood, promote immune system health, support brain health, lower disease risk, and assist with weight loss. They are also tasty and satisfying.

If you want to add mushroom extracts to your diet but don’t have the time to prepare meals, you may consider a mushroom supplement. Supplements are easy to consume and could be more affordable than fresh mushrooms. But you may wonder, which mushroom supplement is best for me and my well-being?

Read on to learn your options so you can make a smart decision about medicinal mushrooms.

Which Mushroom Supplement is Best for Me?


Reishi mushrooms have been nicknamed the “mushroom of immortality.” They are known for their immune-boosting effects. They have been long used in Chinese medicine by practitioners who give them to cancer patients.

A 2012 study showed reishi supplements improved the quality of life in people with colorectal cancer undergoing chemotherapy. A 2008 study revealed the supplement offers immune support in individuals with type 2 diabetes. However, more clinical research is needed to support these claims.

Lion’s Mane

A recent study from the University of Queensland shows lion’s mane’s potential to improve cognitive function and nerve regeneration. A 2019 randomized control trial showed its potential to improve cognitive function in older adults.

The supplement may also promote relaxation. Another trial conducted in 2020 found that it could improve sleep quality in people with sleep disorders.


Cordyceps can improve cardiovascular performance during physical activity. It has been used in traditional medicine for its immune-boosting and antioxidant properties.

A 2010 study showed cordyceps supplements can boost exercise performance in older adults. A 2007 study revealed cordyceps’ potential to improve the quality of life in people with lung cancer undergoing chemotherapy.

Turkey Tail

So-called because they are shaped like a turkey tail, these mushrooms are known for their immune and gut health-boosting properties. A 2008 randomized controlled trial showed that they can improve immune function and gut microbiota in healthy adults. A 2012 study revealed that turkey tail mushrooms may improve the quality of life in people with breast cancer undergoing chemotherapy.


Chaga mushrooms are rich in antioxidants and may reduce inflammation and lower blood sugar and cholesterol. A 2016 study established its immune-boosting benefits. Some 2010 research revealed its potential to boost immunity in people with hepatitis B.

Other studies have suggested that chaga may have anti-inflammatory and anticancer properties. More studies are needed to determine its health benefits.


Shiitake has been shown to produce various health benefits. It may boost immunity, reduce inflammation, and help treat cancer.

A 2015 study showed shiitake improves several markers of immune health. Some 2014 research revealed that it may lower cholesterol in people with high cholesterol.

Other Considerations

Here are other things to consider when deciding which mushroom supplement is best for me.

  • Brand reputation: Source supplements from a brand that has good customer reviews and uses lab testing.
  • Supplement Form: Mushroom supplements are generally available in pill or powder form. Choose the one that is best suited to your lifestyle.
  • Side Effects: Different mushrooms can produce different side effects and interactions. Choose a supplement that is least likely to cause side effects based on your health conditions.

This article answers the question, which mushroom supplement is best for me? It reviews the different types of supplements so you can determine which is suited to your health needs. Which will you add to your diet?

If you’d like to know more, learn about our recommendations for the best mushroom supplement to try.